Assay Detail
Binding
CHEMBL5504663
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant human PI3Kalpha using L-alpha-phosphatidylinositol sodium salt and L-alpha-phosphatidyl-L-serine as substrate incubated for 60 mins in presence of ATP by ADP-glo kinase assay
27
Total Activities
27
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit alpha isoform (CHEMBL4005) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery and Optimization of Pyridazinones as PI3Kδ Selective Inhibitors for Administration by Inhalation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 27 | 6.35 | 7.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5558448 | — | — | 1 | 7.30 |
| CHEMBL5531964 | — | — | 1 | 6.80 |
| CHEMBL5555605 | — | — | 1 | 6.70 |
| CHEMBL5555403 | — | — | 1 | 6.70 |
| CHEMBL5557135 | — | — | 1 | 6.70 |
| CHEMBL5527852 | — | — | 1 | 6.60 |
| CHEMBL5512440 | — | — | 1 | 6.30 |
| CHEMBL5518064 | — | — | 1 | 6.20 |
| CHEMBL5542678 | — | — | 1 | 6.20 |
| CHEMBL5542223 | — | — | 1 | 6.10 |
| CHEMBL5543016 | — | — | 1 | 6.00 |
| CHEMBL5558076 | — | — | 1 | 6.00 |
| CHEMBL5517938 | — | — | 1 | 6.00 |
| CHEMBL5559126 | — | — | 1 | 5.90 |
| CHEMBL5559413 | — | — | 1 | 5.80 |
| CHEMBL3919512 | — | — | 1 | - |
| CHEMBL5517641 | — | — | 1 | - |
| CHEMBL5517797 | — | — | 1 | - |
| CHEMBL5555574 | — | — | 1 | - |
| CHEMBL5559112 | — | — | 1 | - |
| CHEMBL5512540 | — | — | 1 | - |
| CHEMBL5505948 | — | — | 1 | - |
| CHEMBL5556699 | — | — | 1 | - |
| CHEMBL5505905 | — | — | 1 | - |
| CHEMBL5555181 | — | — | 1 | - |
| CHEMBL5532174 | — | — | 1 | - |
| CHEMBL5542654 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5558448 | — | IC50 | = | 50.12 | nM | 7.30 |
| CHEMBL5531964 | — | IC50 | = | 158.49 | nM | 6.80 |
| CHEMBL5555605 | — | IC50 | = | 199.53 | nM | 6.70 |
| CHEMBL5555403 | — | IC50 | = | 199.53 | nM | 6.70 |
| CHEMBL5557135 | — | IC50 | = | 199.53 | nM | 6.70 |
| CHEMBL5527852 | — | IC50 | = | 251.19 | nM | 6.60 |
| CHEMBL5512440 | — | IC50 | = | 501.19 | nM | 6.30 |
| CHEMBL5518064 | — | IC50 | = | 630.96 | nM | 6.20 |
| CHEMBL5542678 | — | IC50 | = | 630.96 | nM | 6.20 |
| CHEMBL5542223 | — | IC50 | = | 794.33 | nM | 6.10 |
| CHEMBL5543016 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL5558076 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL5517938 | — | IC50 | = | 1000.0 | nM | 6.00 |
| CHEMBL5559126 | — | IC50 | = | 1258.93 | nM | 5.90 |
| CHEMBL5559413 | — | IC50 | = | 1584.89 | nM | 5.80 |
| CHEMBL3919512 | — | IC50 | > | 25118.86 | nM | - |
| CHEMBL5517641 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5517797 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5555574 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5559112 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5512540 | — | IC50 | > | 25118.86 | nM | - |
| CHEMBL5505948 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5556699 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5505905 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5555181 | — | IC50 | > | 25118.86 | nM | - |
| CHEMBL5532174 | — | IC50 | > | 10000.0 | nM | - |
| CHEMBL5542654 | — | IC50 | > | 10000.0 | nM | - |