Assay Detail
Binding
CHEMBL5504818
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of thrombin (unknown origin) using H-D-Phe-Pip-Arg-pNA-2HCl as substrate incubated for 20 mins followed by substrate addition by spectrophotometric analysis
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery of Highly Selective, Potent, Covalent, and Orally Bioavailable Factor XIIa Inhibitors for the Treatment of Thrombo-Inflammation.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 5.16 | 6.44 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4776259 | — | — | 1 | 6.44 |
| CHEMBL5517985 | — | — | 1 | 5.16 |
| CHEMBL4761275 | — | — | 1 | 4.80 |
| CHEMBL5556274 | — | — | 1 | 4.70 |
| CHEMBL5557890 | — | — | 1 | 4.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4776259 | — | IC50 | = | 360.0 | nM | 6.44 |
| CHEMBL5517985 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL4761275 | — | IC50 | = | 15700.0 | nM | 4.80 |
| CHEMBL5556274 | — | IC50 | = | 20000.0 | nM | 4.70 |
| CHEMBL5557890 | — | IC50 | = | 20000.0 | nM | 4.70 |