Assay Detail
Binding
CHEMBL5505028
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of BFL-1 (unknown origin)/FITC-conjugated Bid BH3 peptide (unknown origin) interaction by fluorescence polarization assay
3
Total Activities
3
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Discovery of a Covalent Inhibitor That Overcame Resistance to Venetoclax in AML Cells Overexpressing BFL-1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 5.99 | 6.40 |
| EC50 | 1 | 5.89 | 5.89 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1271764 | — | — | 1 | 6.40 |
| CHEMBL5281728 | — | — | 1 | 5.89 |
| CHEMBL1417970 | — | — | 1 | 5.58 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1271764 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL5281728 | — | EC50 | = | 1300.0 | nM | 5.89 |
| CHEMBL1417970 | — | IC50 | = | 2600.0 | nM | 5.58 |