Assay Detail
Binding
CHEMBL5505037
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of MCL-1 (unknown origin)/FAM-BID (unknown origin) interaction measured by fluorescence polarization assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Target
Induced myeloid leukemia cell differentiation protein Mcl-1/BH3-interacting domain death agonist (CHEMBL3430886) ↗| Type | PROTEIN-PROTEIN INTERACTION |
| Organism | Homo sapiens |
Publication
Discovery of a Covalent Inhibitor That Overcame Resistance to Venetoclax in AML Cells Overexpressing BFL-1.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Ki | 10 | 5.54 | 6.03 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4576854 | — | — | 1 | 6.03 |
| CHEMBL5523629 | — | — | 1 | 5.90 |
| CHEMBL5558391 | — | — | 1 | 5.63 |
| CHEMBL5542092 | — | — | 1 | 5.48 |
| CHEMBL3137309 | VENETOCLAX | 4.0 | 1 | 5.43 |
| CHEMBL5527957 | — | — | 1 | 5.38 |
| CHEMBL5558580 | — | — | 1 | 5.36 |
| CHEMBL5555333 | — | — | 1 | 5.35 |
| CHEMBL5512573 | — | — | 1 | 5.32 |
| CHEMBL4788274 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4576854 | — | Ki | = | 932.0 | nM | 6.03 |
| CHEMBL5523629 | — | Ki | = | 1260.0 | nM | 5.90 |
| CHEMBL5558391 | — | Ki | = | 2357.0 | nM | 5.63 |
| CHEMBL5542092 | — | Ki | = | 3295.0 | nM | 5.48 |
| CHEMBL3137309 | VENETOCLAX | Ki | = | 3748.0 | nM | 5.43 |
| CHEMBL5527957 | — | Ki | = | 4161.0 | nM | 5.38 |
| CHEMBL5558580 | — | Ki | = | 4404.0 | nM | 5.36 |
| CHEMBL5555333 | — | Ki | = | 4508.0 | nM | 5.35 |
| CHEMBL5512573 | — | Ki | = | 4758.0 | nM | 5.32 |
| CHEMBL4788274 | — | Ki | < | 0.1 | nM | - |