Assay Detail
Binding
CHEMBL5505507
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of C-terminal His-tagged SARS-CoV-2 PLpro BetaCoV/Wuhan/WIV04/2019 expressed in Escherichia coli BL21(DE3) using ISG-AMC substrate incubated for 3 hrs by FRET analysis
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Replicase polyprotein 1ab (CHEMBL4523582) ↗| Type | SINGLE PROTEIN |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
New Strategies for Responding to SARS-CoV-2: The Present and Future of Dual-Target Drugs.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 7.52 | 7.92 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4852855 | — | — | 1 | 7.92 |
| CHEMBL2315036 | — | — | 1 | 7.70 |
| CHEMBL5557204 | — | — | 1 | 7.22 |
| CHEMBL5542652 | — | — | 1 | 7.22 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4852855 | — | IC50 | = | 12.0 | nM | 7.92 |
| CHEMBL2315036 | — | IC50 | = | 20.0 | nM | 7.70 |
| CHEMBL5557204 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL5542652 | — | IC50 | = | 60.0 | nM | 7.22 |