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Assay Detail

CHEMBL5505636

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Anti-ferroptotic activity against glutamate-induced rat Hippocampus assessed as inhibition of ferroptosis
1
Total Activities
1
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Rattus norvegicus
Tissue Hippocampus
Confidence 1 — Organism
Curated By Autocuration

Target

Hippocampus (CHEMBL613631)
Type TISSUE
Organism Rattus norvegicus

Publication

Discovery of New Phenyltetrazolium Derivatives as Ferroptosis Inhibitors for Treating Ischemic Stroke: An Example Development from Free Radical Scavengers.
Lu Y, Shen Z, Xu Y, Lin H, Shen L, Jin Y, Guo Y, Lu J, Li L, Zhuang Y, Jin Y, Zhuang W, Huang W, Dong X, Dai H, Che J.
J Med Chem (2024) 67 : 11712 -11731
PubMed 38996382 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 1 7.05 7.05

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL3633556 1 7.05

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL3633556 IC50 = 90.0 nM 7.05