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Target Snapshot

CHEMBL613631 Target Snapshot

Hippocampus · TISSUE · Rattus norvegicus

240Compounds
260Assays
0Approved Drugs
17.0Activities
Free Research Context

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Broader Open DB context

Frame the target before identity details

Structured disease, protein, and project context should read before the lower-level identity rail.

As of 2026-09-14

Confirm a stable target identifier before relying on this context across project surfaces.

Review focus
Open DB context pending

Confirm a stable target identifier before relying on this context across project surfaces.

ChEMBL component mapping + Open Targets-ready proxy + ChEMBL 36 via Core Engine 2026-09-14
Open source guide
Identity Layer

Cross-source identity

Keep the review anchor, source IDs, and context contract aligned before reusing this target elsewhere.

This review treats Hippocampus as ChEMBL target CHEMBL613631. Disease framing currently uses the Open Targets-ready proxy contract.

Review anchor
Hippocampus
TISSUE · Rattus norvegicus
As of 2026-09-14
ChEMBL target ID
CHEMBL613631
Primary anchor for compounds, assays, approvals, and exports
ChEMBL 36 via Core Engine As of 2026-09-14
www.ebi.ac.uk
Disease evidence contract
Open Targets-ready proxy
ChEMBL drug mechanism + indication proxy
ChEMBL drug mechanism + indication proxy As of 2026-09-14
www.ebi.ac.uk

Reuse the same identifiers in notes, watch rules, exports, and review packs so provenance stays stable across surfaces.

Source Guidance

Start with the right source

Choose the first block or source based on the question you are trying to answer.

Need stable target naming and protein identity?
UniProt Target Context
UniProt accession via ChEMBL component mapping

Start here when your first question is whether Hippocampus still has a stable protein naming contract across sources.

Jump to Protein Context
Need disease fit before discussing compounds?
Disease Relevance & Evidence Level
ChEMBL drug mechanism + indication proxy

Use this block first when you need the strongest disease program and evidence level in one place.

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Evidence Card
Review-ready rationale with source-aware context

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Overview

Basic Information

Verify identity, organism, and the fastest next research jumps from the same page.

UniProt Context

UniProt Target Context

Reviewable protein naming and mapping context for this target snapshot.

Protein LabelHippocampus
UniProt AccessionN/A

Hippocampus

Source · UniProt accession via ChEMBL component mapping
Review Cue

How to read this target

Review this target as Hippocampus.

Review nameHippocampus
OrganismRattus norvegicus
Assay Mix

Activity Type Distribution

IC502.0
EC5015.0
Lead Set

Top Inhibitors (by pChEMBL)

ChEMBL IDpChEMBLTypeValue (nM)Phase
CHEMBL5430250 8.54 EC50 2.913 Preclinical
CHEMBL2407300 7.85 EC50 14.0 Preclinical
CHEMBL3037799 7.51 EC50 31.0 Preclinical
CHEMBL508710 7.22 EC50 60.0 Preclinical
CHEMBL405787 7.2 EC50 63.0 Preclinical
CHEMBL402475 7.06 EC50 87.0 Preclinical
CHEMBL3633556 7.05 IC50 90.0 Preclinical
CHEMBL1232313 6.64 EC50 228.0 Preclinical
CHEMBL2407299 6.56 EC50 277.0 Preclinical
CHEMBL4463517 6.42 IC50 385.0 Preclinical
Distribution

pChEMBL Value Distribution

3
5.0
3
5.5
2
6.0
2
6.5
4
7.0
2
7.5
0
8.0
1
8.5
0
9.0
0
9.5
pChEMBL
Assay Landscape

Assay Landscape

260
Total Assays
17
Tested Compounds
3
Assay Types
Functional — 148 assays, 17 compounds
BAO Format Assays Compounds Avg pChEMBL
tissue-based format 109 17 6.5
organism-based format 38 0
assay format 1 0
ADME — 109 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
organism-based format 96 0
tissue-based format 13 0
Toxicity — 3 assays, 0 compounds
BAO Format Assays Compounds Avg pChEMBL
tissue-based format 3 0

Confidence Score Distribution

Source · ChEMBL 36 via Core Engine