Assay Detail
Binding
CHEMBL5505667
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human PI3Kbeta using PI(4,5)P2:PS as substrate in presence of ATP by kinase hotspot assay
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Phosphatidylinositol 4,5-bisphosphate 3-kinase catalytic subunit beta isoform (CHEMBL3145) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of 6-Anilino Imidazo[4,5-<i>c</i>]pyridin-2-ones as Selective DNA-Dependent Protein Kinase Inhibitors and Their Application as Radiosensitizers.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.35 | 8.27 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4297629 | NEDISERTIB | 1.0 | 1 | 8.27 |
| CHEMBL5523360 | — | — | 1 | 6.65 |
| CHEMBL4439259 | AZD-7648 | 1.0 | 1 | 5.41 |
| CHEMBL5542350 | — | — | 1 | 5.05 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4297629 | NEDISERTIB | IC50 | = | 5.35 | nM | 8.27 |
| CHEMBL5523360 | — | IC50 | = | 226.0 | nM | 6.65 |
| CHEMBL4439259 | AZD-7648 | IC50 | = | 3890.0 | nM | 5.41 |
| CHEMBL5542350 | — | IC50 | = | 8830.0 | nM | 5.05 |