Assay Detail
Functional
CHEMBL5506152
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Antiviral activity against SARS-CoV-2 Omicron B.1.351 Beta infected in human Huh-7 cells assessed as reduction of viral replication measured after 48 hrs by luciferase assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
SARS-CoV-2 (CHEMBL4303835) ↗| Type | ORGANISM |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
Targeting SARS-CoV-2 entry processes: The promising potential and future of host-targeted small-molecule inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 5 | 5.89 | 6.83 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL64925 | MG-132 | — | 1 | 6.83 |
| CHEMBL2402203 | — | — | 1 | 6.05 |
| CHEMBL304784 | — | — | 1 | 6.02 |
| CHEMBL5550069 | — | — | 1 | 4.67 |
| CHEMBL4744444 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL64925 | MG-132 | EC50 | = | 147.2 | nM | 6.83 |
| CHEMBL2402203 | — | EC50 | = | 887.7 | nM | 6.05 |
| CHEMBL304784 | — | EC50 | = | 960.0 | nM | 6.02 |
| CHEMBL5550069 | — | EC50 | = | 21540.0 | nM | 4.67 |
| CHEMBL4744444 | — | EC50 | = | 218840.0 | nM | - |