Assay Detail
Binding
CHEMBL5506174
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PIKfyve (unknown origin)
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
1-phosphatidylinositol 3-phosphate 5-kinase (CHEMBL1938222) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Targeting SARS-CoV-2 entry processes: The promising potential and future of host-targeted small-molecule inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.95 | 8.74 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5557909 | — | — | 1 | 8.74 |
| CHEMBL2334586 | — | — | 1 | 8.66 |
| CHEMBL5181163 | — | — | 1 | 8.21 |
| CHEMBL5523484 | — | — | 1 | 8.16 |
| CHEMBL5568317 | — | — | 1 | 8.03 |
| CHEMBL5202422 | — | — | 1 | 7.21 |
| CHEMBL5194568 | — | — | 1 | 6.66 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5557909 | — | IC50 | = | 1.8 | nM | 8.74 |
| CHEMBL2334586 | — | IC50 | = | 2.2 | nM | 8.66 |
| CHEMBL5181163 | — | IC50 | = | 6.1 | nM | 8.21 |
| CHEMBL5523484 | — | IC50 | = | 6.9 | nM | 8.16 |
| CHEMBL5568317 | — | IC50 | = | 9.3 | nM | 8.03 |
| CHEMBL5202422 | — | IC50 | = | 61.0 | nM | 7.21 |
| CHEMBL5194568 | — | IC50 | = | 220.0 | nM | 6.66 |