Assay Detail
Binding
CHEMBL5506181
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human TMPRSS2
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Targeting SARS-CoV-2 entry processes: The promising potential and future of host-targeted small-molecule inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.31 | 9.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL273264 | NAFAMOSTAT | 3.0 | 1 | 9.30 |
| CHEMBL590799 | CAMOSTAT | 3.0 | 1 | 8.41 |
| CHEMBL1185793 | — | — | 1 | 7.16 |
| CHEMBL87563 | GABEXATE | 3.0 | 1 | 6.89 |
| CHEMBL46618 | OTAMIXABAN | 3.0 | 1 | 6.21 |
| CHEMBL147503 | — | — | 1 | 5.91 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL273264 | NAFAMOSTAT | IC50 | = | 0.5 | nM | 9.30 |
| CHEMBL590799 | CAMOSTAT | IC50 | = | 3.9 | nM | 8.41 |
| CHEMBL1185793 | — | IC50 | = | 70.0 | nM | 7.16 |
| CHEMBL87563 | GABEXATE | IC50 | = | 130.0 | nM | 6.89 |
| CHEMBL46618 | OTAMIXABAN | IC50 | = | 620.0 | nM | 6.21 |
| CHEMBL147503 | — | IC50 | = | 1240.0 | nM | 5.91 |