Assay Detail
Functional
CHEMBL5506733
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Agonist activity at rat mGluR2 receptor expressed in HEK293 cells by IP-1 HTRF assay
14
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Rattus norvegicus |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Metabotropic glutamate receptor 2 (CHEMBL2851) ↗| Type | SINGLE PROTEIN |
| Organism | Rattus norvegicus |
Publication
Synthesis and pharmacological characterization of conformationally restricted 2-amino-Adipic acid analogs and carboxycyclopropyl glycines as selective metabotropic glutamate 2 receptor agonists.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 14 | 6.07 | 9.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL275079 | LY-379268 | — | 2 | 9.22 |
| CHEMBL5532032 | — | — | 2 | 7.09 |
| CHEMBL5555290 | — | — | 2 | 5.75 |
| CHEMBL5560070 | — | — | 2 | 5.39 |
| CHEMBL5558260 | — | — | 2 | 5.12 |
| CHEMBL5517920 | — | — | 2 | 5.05 |
| CHEMBL5537101 | — | — | 2 | 5.00 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL275079 | LY-379268 | EC50 | = | 0.6 | nM | 9.22 |
| CHEMBL275079 | LY-379268 | EC50 | = | 0.6166 | nM | 9.21 |
| CHEMBL5532032 | — | EC50 | = | 82.0 | nM | 7.09 |
| CHEMBL5532032 | — | EC50 | = | 81.28 | nM | 7.09 |
| CHEMBL5555290 | — | EC50 | = | 1798.0 | nM | 5.75 |
| CHEMBL5555290 | — | EC50 | = | 1819.7 | nM | 5.74 |
| CHEMBL5560070 | — | EC50 | = | 4100.0 | nM | 5.39 |
| CHEMBL5560070 | — | EC50 | = | 4073.8 | nM | 5.39 |
| CHEMBL5558260 | — | EC50 | = | 7500.0 | nM | 5.12 |
| CHEMBL5558260 | — | EC50 | = | 7585.78 | nM | 5.12 |
| CHEMBL5517920 | — | EC50 | = | 8900.0 | nM | 5.05 |
| CHEMBL5517920 | — | EC50 | = | 8912.51 | nM | 5.05 |
| CHEMBL5537101 | — | EC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL5537101 | — | EC50 | = | 15848.93 | nM | 4.80 |