Assay Detail
Binding
CHEMBL5506765
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Inhibition of mushroom tyrosinase using L-DOPA as substrate preincubated for 10 mins followed by substrate addition measured after 10 mins by absorbance based spectramax microplate reader assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Agaricus bisporus |
| Confidence | 5 — Multiple protein complex / RNA |
| Curated By | Autocuration |
Publication
Design and synthesis of 4-amino-2',4'-dihydroxyindanone derivatives as potent inhibitors of tyrosinase and melanin biosynthesis in human melanoma cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 6.99 | 8.22 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5555033 | — | — | 1 | 8.22 |
| CHEMBL5562348 | — | — | 1 | 8.05 |
| CHEMBL5557324 | — | — | 1 | 7.85 |
| CHEMBL5558420 | — | — | 1 | 7.85 |
| CHEMBL5563317 | — | — | 1 | 7.72 |
| CHEMBL5556099 | — | — | 1 | 7.57 |
| CHEMBL5566780 | — | — | 1 | 7.22 |
| CHEMBL5567977 | — | — | 1 | 7.08 |
| CHEMBL5532313 | — | — | 1 | 7.07 |
| CHEMBL5408197 | — | — | 1 | 7.05 |
| CHEMBL5555075 | — | — | 1 | 7.00 |
| CHEMBL5558133 | — | — | 1 | 6.82 |
| CHEMBL5558083 | — | — | 1 | 6.80 |
| CHEMBL5532330 | — | — | 1 | 6.80 |
| CHEMBL5560542 | — | — | 1 | 6.75 |
| CHEMBL5557491 | — | — | 1 | 6.58 |
| CHEMBL5566466 | — | — | 1 | 6.41 |
| CHEMBL5527846 | — | — | 1 | 6.34 |
| CHEMBL5557086 | — | — | 1 | 6.22 |
| CHEMBL287556 | KOJIC ACID | — | 1 | 4.48 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5555033 | — | IC50 | = | 6.0 | nM | 8.22 |
| CHEMBL5562348 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL5557324 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL5558420 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL5563317 | — | IC50 | = | 19.0 | nM | 7.72 |
| CHEMBL5556099 | — | IC50 | = | 27.0 | nM | 7.57 |
| CHEMBL5566780 | — | IC50 | = | 60.0 | nM | 7.22 |
| CHEMBL5567977 | — | IC50 | = | 83.0 | nM | 7.08 |
| CHEMBL5532313 | — | IC50 | = | 86.0 | nM | 7.07 |
| CHEMBL5408197 | — | IC50 | = | 90.0 | nM | 7.05 |
| CHEMBL5555075 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL5558133 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL5558083 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL5532330 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL5560542 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL5557491 | — | IC50 | = | 260.0 | nM | 6.58 |
| CHEMBL5566466 | — | IC50 | = | 390.0 | nM | 6.41 |
| CHEMBL5527846 | — | IC50 | = | 460.0 | nM | 6.34 |
| CHEMBL5557086 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL287556 | KOJIC ACID | IC50 | = | 33000.0 | nM | 4.48 |