Assay Detail
Binding
CHEMBL5506766
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of tyrosinase in human MNT-1 cells using L-DOPA as substrate preincubated for 10 mins followed by substrate addition measured after 180 mins by absorbance based spectramax microplate reader assay
20
Total Activities
20
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | MNT-1 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of 4-amino-2',4'-dihydroxyindanone derivatives as potent inhibitors of tyrosinase and melanin biosynthesis in human melanoma cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 20 | 5.72 | 6.85 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5562348 | — | — | 1 | 6.85 |
| CHEMBL5558420 | — | — | 1 | 6.82 |
| CHEMBL4743159 | — | — | 1 | 6.77 |
| CHEMBL5555033 | — | — | 1 | 6.75 |
| CHEMBL5566780 | — | — | 1 | 6.46 |
| CHEMBL5556099 | — | — | 1 | 6.14 |
| CHEMBL5557086 | — | — | 1 | 6.07 |
| CHEMBL5557324 | — | — | 1 | 6.05 |
| CHEMBL5558083 | — | — | 1 | 5.75 |
| CHEMBL5566466 | — | — | 1 | 5.70 |
| CHEMBL5527846 | — | — | 1 | 5.50 |
| CHEMBL5555075 | — | — | 1 | 5.36 |
| CHEMBL5558133 | — | — | 1 | 5.05 |
| CHEMBL5563317 | — | — | 1 | 4.82 |
| CHEMBL5567977 | — | — | 1 | 4.62 |
| CHEMBL5557491 | — | — | 1 | 4.30 |
| CHEMBL5532313 | — | — | 1 | 4.18 |
| CHEMBL5532330 | — | — | 1 | - |
| CHEMBL287556 | KOJIC ACID | — | 1 | - |
| CHEMBL5560542 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5562348 | — | IC50 | = | 140.0 | nM | 6.85 |
| CHEMBL5558420 | — | IC50 | = | 150.0 | nM | 6.82 |
| CHEMBL4743159 | — | IC50 | = | 170.0 | nM | 6.77 |
| CHEMBL5555033 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL5566780 | — | IC50 | = | 350.0 | nM | 6.46 |
| CHEMBL5556099 | — | IC50 | = | 720.0 | nM | 6.14 |
| CHEMBL5557086 | — | IC50 | = | 850.0 | nM | 6.07 |
| CHEMBL5557324 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL5558083 | — | IC50 | = | 1800.0 | nM | 5.75 |
| CHEMBL5566466 | — | IC50 | = | 2000.0 | nM | 5.70 |
| CHEMBL5527846 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL5555075 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL5558133 | — | IC50 | = | 9000.0 | nM | 5.05 |
| CHEMBL5563317 | — | IC50 | = | 15000.0 | nM | 4.82 |
| CHEMBL5567977 | — | IC50 | = | 24000.0 | nM | 4.62 |
| CHEMBL5557491 | — | IC50 | = | 50000.0 | nM | 4.30 |
| CHEMBL5532313 | — | IC50 | = | 66000.0 | nM | 4.18 |
| CHEMBL5532330 | — | IC50 | > | 100000.0 | nM | - |
| CHEMBL287556 | KOJIC ACID | IC50 | > | 100000.0 | nM | - |
| CHEMBL5560542 | — | IC50 | > | 100000.0 | nM | - |