Assay Detail
Binding
CHEMBL5506771
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of His-tagged human tyrosinase expressed in HEK293 cells using L-DOPA as substrate by microplate reader analysis
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | HEK293 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design and synthesis of 4-amino-2',4'-dihydroxyindanone derivatives as potent inhibitors of tyrosinase and melanin biosynthesis in human melanoma cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 4.68 | 4.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL450195 | RUCINOL | — | 1 | 4.68 |
| CHEMBL24147 | RESORCINOL | -1.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL450195 | RUCINOL | IC50 | = | 21000.0 | nM | 4.68 |
| CHEMBL24147 | RESORCINOL | IC50 | > | 3000000.0 | nM | - |