Assay Detail
Binding
CHEMBL5506776
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of COX-2 (unknown origin) using arachidonic acid as substrate preincubated for 10 mins followed by substrate addition and measured after 5 mins by fluorescence based analysis
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Hybrids of selective COX-2 inhibitors and active derivatives of edaravone as COX-2 selective NSAIDs with free radical scavenging activity: Design, synthesis and biological activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 7.15 | 7.68 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL42485 | DUP-697 | — | 1 | 7.68 |
| CHEMBL5568253 | — | — | 1 | 7.24 |
| CHEMBL5565096 | — | — | 1 | 7.12 |
| CHEMBL5568511 | — | — | 1 | 6.87 |
| CHEMBL5568474 | — | — | 1 | 6.84 |
| CHEMBL290916 | EDARAVONE | 4.0 | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL42485 | DUP-697 | IC50 | = | 21.0 | nM | 7.68 |
| CHEMBL5568253 | — | IC50 | = | 58.0 | nM | 7.24 |
| CHEMBL5565096 | — | IC50 | = | 75.0 | nM | 7.12 |
| CHEMBL5568511 | — | IC50 | = | 134.0 | nM | 6.87 |
| CHEMBL5568474 | — | IC50 | = | 144.0 | nM | 6.84 |
| CHEMBL290916 | EDARAVONE | IC50 | - | — | - |