Assay Detail
Functional
CHEMBL5506805
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiplasmodial activity against sorbitol-synchronized ring stage chloroquine sensitive Plasmodium falciparum 3D7 infected in erythrocytes measured after 48 hrs by SYBR green dye based fluorescence analysis
16
Total Activities
16
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Cell Type | Erythrocyte |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of new piperaquine hybrid analogs linked by triazolopyrimidine and pyrazolopyrimidine scaffolds with antiplasmodial and transmission blocking activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 16 | 6.86 | 9.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1450 | ATOVAQUONE | 4.0 | 1 | 9.00 |
| CHEMBL1956285 | DSM-265 | 2.0 | 1 | 8.40 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 7.96 |
| CHEMBL5557769 | — | — | 1 | 7.34 |
| CHEMBL5563645 | — | — | 1 | 7.19 |
| CHEMBL5560017 | — | — | 1 | 6.96 |
| CHEMBL5559121 | — | — | 1 | 6.92 |
| CHEMBL5555313 | — | — | 1 | 6.84 |
| CHEMBL5542727 | — | — | 1 | 6.60 |
| CHEMBL5518014 | — | — | 1 | 6.51 |
| CHEMBL5559610 | — | — | 1 | 6.40 |
| CHEMBL5564121 | — | — | 1 | 6.17 |
| CHEMBL5558306 | — | — | 1 | 6.08 |
| CHEMBL5562619 | — | — | 1 | 5.36 |
| CHEMBL5566191 | — | — | 1 | 5.16 |
| CHEMBL5566294 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1450 | ATOVAQUONE | IC50 | = | 1.0 | nM | 9.00 |
| CHEMBL1956285 | DSM-265 | IC50 | = | 4.0 | nM | 8.40 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL5557769 | — | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL5563645 | — | IC50 | = | 64.0 | nM | 7.19 |
| CHEMBL5560017 | — | IC50 | = | 110.0 | nM | 6.96 |
| CHEMBL5559121 | — | IC50 | = | 120.0 | nM | 6.92 |
| CHEMBL5555313 | — | IC50 | = | 145.0 | nM | 6.84 |
| CHEMBL5542727 | — | IC50 | = | 250.0 | nM | 6.60 |
| CHEMBL5518014 | — | IC50 | = | 310.0 | nM | 6.51 |
| CHEMBL5559610 | — | IC50 | = | 400.0 | nM | 6.40 |
| CHEMBL5564121 | — | IC50 | = | 673.0 | nM | 6.17 |
| CHEMBL5558306 | — | IC50 | = | 840.0 | nM | 6.08 |
| CHEMBL5562619 | — | IC50 | = | 4400.0 | nM | 5.36 |
| CHEMBL5566191 | — | IC50 | = | 7000.0 | nM | 5.16 |
| CHEMBL5566294 | — | IC50 | > | 10000.0 | nM | - |