Compound Detail
CHEMBL5562619
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Basic Information
| ChEMBL ID | CHEMBL5562619 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | ICPOQVCPJDHPLH-UHFFFAOYSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
392.9
MW (Da)
3.87
ALogP
6
HBA
0
HBD
49.6
PSA (Ų)
0.52
QED
0
Ro5 Violations
2
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.36
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Plasmodium falciparum CHEMBL364 | IC50 | 5.36 | 5.36 | 4400.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Plasmodium falciparum | IC50 | = | 4400.0 | nM | 5.36 | Antiplasmodial activity against sorbitol-synchronized ring stage chloroquine sen... | 38290351 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 38290351 | 10.1016/j.ejmech.2024.116163 | Plasmodium falciparum | 2 |
| 38290351 | 10.1016/j.ejmech.2024.116163 | Dihydroorotate dehydrogenase (quinone), mitochondrial | 2 |
| 38290351 | 10.1016/j.ejmech.2024.116163 | HepG2 | 1 |
Data from ChEMBL 36 via Core Engine