Assay Detail
Functional
CHEMBL5506806
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiplasmodial activity against sorbitol-synchronized ring stage chloroquine resistant Plasmodium falciparum K1 infected in erythrocytes measured after 48 hrs by SYBR green dye based fluorescence analysis
14
Total Activities
14
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Plasmodium falciparum |
| Cell Type | Erythrocyte |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Discovery of new piperaquine hybrid analogs linked by triazolopyrimidine and pyrazolopyrimidine scaffolds with antiplasmodial and transmission blocking activities.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 14 | 6.49 | 7.15 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5557769 | — | — | 1 | 7.15 |
| CHEMBL5563645 | — | — | 1 | 6.75 |
| CHEMBL5559121 | — | — | 1 | 6.68 |
| CHEMBL5542727 | — | — | 1 | 6.66 |
| CHEMBL76 | CHLOROQUINE | 4.0 | 1 | 6.64 |
| CHEMBL5518014 | — | — | 1 | 6.52 |
| CHEMBL5560017 | — | — | 1 | 6.52 |
| CHEMBL5555313 | — | — | 1 | 6.30 |
| CHEMBL5558306 | — | — | 1 | 6.19 |
| CHEMBL5564121 | — | — | 1 | 5.52 |
| CHEMBL5559610 | — | — | 1 | - |
| CHEMBL5566294 | — | — | 1 | - |
| CHEMBL5566191 | — | — | 1 | - |
| CHEMBL5562619 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5557769 | — | IC50 | = | 71.0 | nM | 7.15 |
| CHEMBL5563645 | — | IC50 | = | 180.0 | nM | 6.75 |
| CHEMBL5559121 | — | IC50 | = | 210.0 | nM | 6.68 |
| CHEMBL5542727 | — | IC50 | = | 220.0 | nM | 6.66 |
| CHEMBL76 | CHLOROQUINE | IC50 | = | 230.0 | nM | 6.64 |
| CHEMBL5518014 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL5560017 | — | IC50 | = | 300.0 | nM | 6.52 |
| CHEMBL5555313 | — | IC50 | = | 500.0 | nM | 6.30 |
| CHEMBL5558306 | — | IC50 | = | 640.0 | nM | 6.19 |
| CHEMBL5564121 | — | IC50 | = | 3000.0 | nM | 5.52 |
| CHEMBL5559610 | — | IC50 | - | — | - | |
| CHEMBL5566294 | — | IC50 | - | — | - | |
| CHEMBL5566191 | — | IC50 | - | — | - | |
| CHEMBL5562619 | — | IC50 | - | — | - |