Assay Detail
Binding
CHEMBL5506837
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Inhibition of human ATR/ATRIP using GST-tagged p53 as substrate in presence of 3 uM ATP by AlphaScreen assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 7 — Homologous single protein target |
| Curated By | Autocuration |
Publication
Discovery of the Potent and Selective ATR Inhibitor Camonsertib (RP-3500).
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 7.35 | 8.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL2325697 | — | — | 1 | 8.30 |
| CHEMBL5557486 | — | — | 1 | 8.15 |
| CHEMBL4285417 | CERALASERTIB | 3.0 | 1 | 7.85 |
| CHEMBL5568349 | — | — | 1 | 7.40 |
| CHEMBL5568570 | — | — | 1 | 7.00 |
| CHEMBL4650286 | M4344 | 1.0 | 1 | 6.80 |
| CHEMBL5556905 | — | — | 1 | 6.80 |
| CHEMBL4647810 | ELIMUSERTIB | 1.0 | 1 | 6.48 |
| CHEMBL3989870 | BERZOSERTIB | 2.0 | 1 | - |
| CHEMBL5518146 | — | — | 1 | - |
| CHEMBL5557127 | — | — | 1 | - |
| CHEMBL5532160 | — | — | 1 | - |
| CHEMBL5564966 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL2325697 | — | IC50 | = | 5.0 | nM | 8.30 |
| CHEMBL5557486 | — | IC50 | = | 7.0 | nM | 8.15 |
| CHEMBL4285417 | CERALASERTIB | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL5568349 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL5568570 | — | IC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4650286 | M4344 | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL5556905 | — | IC50 | = | 160.0 | nM | 6.80 |
| CHEMBL4647810 | ELIMUSERTIB | IC50 | = | 330.0 | nM | 6.48 |
| CHEMBL3989870 | BERZOSERTIB | IC50 | < | 1.0 | nM | - |
| CHEMBL5518146 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5557127 | — | IC50 | > | 1000.0 | nM | - |
| CHEMBL5532160 | — | IC50 | > | 700.0 | nM | - |
| CHEMBL5564966 | — | IC50 | > | 1000.0 | nM | - |