Assay Detail
Binding
CHEMBL5507156
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of GLK (unknown origin)
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Mitogen-activated protein kinase kinase kinase kinase 3 (CHEMBL5432) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Discovery of novel, potent, selective and orally bioavailable HPK1 inhibitor for enhancing the efficacy of anti-PD-L1 antibody.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.82 | 8.12 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5558185 | — | — | 1 | 8.12 |
| CHEMBL5555917 | — | — | 1 | 7.99 |
| CHEMBL5555788 | — | — | 1 | 7.83 |
| CHEMBL5555659 | — | — | 1 | 7.65 |
| CHEMBL5558967 | — | — | 1 | 7.52 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5558185 | — | IC50 | = | 7.56 | nM | 8.12 |
| CHEMBL5555917 | — | IC50 | = | 10.22 | nM | 7.99 |
| CHEMBL5555788 | — | IC50 | = | 14.67 | nM | 7.83 |
| CHEMBL5555659 | — | IC50 | = | 22.32 | nM | 7.65 |
| CHEMBL5558967 | — | IC50 | = | 30.24 | nM | 7.52 |