Assay Detail
Binding
CHEMBL5507306
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Inhibition of JAK3 (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Design, synthesis and evaluation of C-5 substituted pyrrolopyridine derivatives as potent Janus Kinase 1 inhibitors with excellent selectivity.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.14 | 9.40 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL221959 | TOFACITINIB | 4.0 | 1 | 9.40 |
| CHEMBL1789941 | RUXOLITINIB | 4.0 | 1 | 6.37 |
| CHEMBL3622821 | UPADACITINIB | 4.0 | 1 | 5.64 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL221959 | TOFACITINIB | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL1789941 | RUXOLITINIB | IC50 | = | 428.0 | nM | 6.37 |
| CHEMBL3622821 | UPADACITINIB | IC50 | = | 2304.0 | nM | 5.64 |