Assay Detail
Binding
CHEMBL5507347
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to recombinant human AKR1C3 in presence of NADP+ by MST assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Aldo-keto reductase family 1 member C3 (CHEMBL4681) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Structure-guided optimization of 3-hydroxybenzoisoxazole derivatives as inhibitors of Aldo-keto reductase 1C3 (AKR1C3) to target prostate cancer.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 3 | 5.47 | 5.60 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5555217 | — | — | 1 | 5.60 |
| CHEMBL5557454 | — | — | 1 | 5.52 |
| CHEMBL4238437 | — | — | 1 | 5.28 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5555217 | — | Kd | = | 2500.0 | nM | 5.60 |
| CHEMBL5557454 | — | Kd | = | 3000.0 | nM | 5.52 |
| CHEMBL4238437 | — | Kd | = | 5200.0 | nM | 5.28 |