Assay Detail
Functional
CHEMBL5508026
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Antiproliferative activity against human HCT-116 cells by MTT assay
13
Total Activities
13
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Thiadiazole-, selenadiazole- and triazole-fused anthraquinones as G-quadruplex targeting anticancer compounds.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 13 | 5.59 | 6.26 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | 4.0 | 1 | 6.26 |
| CHEMBL5562375 | — | — | 1 | 6.22 |
| CHEMBL5562616 | — | — | 1 | 6.10 |
| CHEMBL3745930 | — | — | 1 | 5.92 |
| CHEMBL5563694 | — | — | 1 | 5.54 |
| CHEMBL469320 | — | — | 1 | 5.50 |
| CHEMBL5518099 | — | — | 1 | 5.43 |
| CHEMBL5567587 | — | — | 1 | 5.11 |
| CHEMBL5560792 | — | — | 1 | 5.00 |
| CHEMBL472033 | — | — | 1 | 4.77 |
| CHEMBL5532602 | — | — | 1 | - |
| CHEMBL5568358 | — | — | 1 | - |
| CHEMBL5559574 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL53463 | DOXORUBICIN | IC50 | = | 550.0 | nM | 6.26 |
| CHEMBL5562375 | — | IC50 | = | 600.0 | nM | 6.22 |
| CHEMBL5562616 | — | IC50 | = | 800.0 | nM | 6.10 |
| CHEMBL3745930 | — | IC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL5563694 | — | IC50 | = | 2900.0 | nM | 5.54 |
| CHEMBL469320 | — | IC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL5518099 | — | IC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL5567587 | — | IC50 | = | 7800.0 | nM | 5.11 |
| CHEMBL5560792 | — | IC50 | = | 10000.0 | nM | 5.00 |
| CHEMBL472033 | — | IC50 | = | 17000.0 | nM | 4.77 |
| CHEMBL5532602 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5568358 | — | IC50 | > | 50000.0 | nM | - |
| CHEMBL5559574 | — | IC50 | > | 50000.0 | nM | - |