Assay Detail
Binding
CHEMBL5508244
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Inhibition of Aurora B (unknown origin)
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel sulfonamide-indolinone hybrids targeting mitochondrial respiration of breast cancer cells.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 7.94 | 8.52 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL3699142 | — | — | 1 | 8.52 |
| CHEMBL5549914 | — | — | 1 | 7.98 |
| CHEMBL274654 | ORANTINIB | 3.0 | 1 | 7.33 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL3699142 | — | IC50 | = | 3.0 | nM | 8.52 |
| CHEMBL5549914 | — | IC50 | = | 10.5 | nM | 7.98 |
| CHEMBL274654 | ORANTINIB | IC50 | = | 47.0 | nM | 7.33 |