Assay Detail
Functional
CHEMBL5508565
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against SARS-CoV-2 infected in Vero cells assessed as reduction in viral yield measured after 48 hrs by qRT-PCR analysis
30
Total Activities
15
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Cell Type | Vero |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
SARS-CoV-2 (CHEMBL4303835) ↗| Type | ORGANISM |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
Synthesis and biological evaluation of novel peptidomimetic inhibitors of the coronavirus 3C-like protease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 5.40 | 5.66 |
| EC90 | 15 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5562068 | — | — | 2 | 5.66 |
| CHEMBL4129318 | — | — | 2 | 5.58 |
| CHEMBL4065616 | REMDESIVIR | 4.0 | 2 | 5.50 |
| CHEMBL4802135 | NIRMATRELVIR | 4.0 | 2 | 5.43 |
| CHEMBL5560653 | — | — | 2 | 5.35 |
| CHEMBL5532059 | — | — | 2 | 5.34 |
| CHEMBL5568017 | — | — | 2 | 5.33 |
| CHEMBL5561582 | — | — | 2 | 5.21 |
| CHEMBL5564091 | — | — | 2 | 5.17 |
| CHEMBL5555908 | — | — | 2 | - |
| CHEMBL5565189 | — | — | 2 | - |
| CHEMBL4128616 | — | — | 2 | - |
| CHEMBL5568375 | — | — | 2 | - |
| CHEMBL5560592 | — | — | 2 | - |
| CHEMBL5568534 | — | — | 2 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5562068 | — | EC50 | = | 2200.0 | nM | 5.66 |
| CHEMBL4129318 | — | EC50 | = | 2600.0 | nM | 5.58 |
| CHEMBL4065616 | REMDESIVIR | EC50 | = | 3200.0 | nM | 5.50 |
| CHEMBL4802135 | NIRMATRELVIR | EC50 | = | 3700.0 | nM | 5.43 |
| CHEMBL5560653 | — | EC50 | = | 4500.0 | nM | 5.35 |
| CHEMBL5532059 | — | EC50 | = | 4600.0 | nM | 5.34 |
| CHEMBL5568017 | — | EC50 | = | 4700.0 | nM | 5.33 |
| CHEMBL5561582 | — | EC50 | = | 6100.0 | nM | 5.21 |
| CHEMBL5564091 | — | EC50 | = | 6700.0 | nM | 5.17 |
| CHEMBL5565189 | — | EC90 | > | 10.0 | uM | - |
| CHEMBL5555908 | — | EC90 | > | 10.0 | uM | - |
| CHEMBL4129318 | — | EC90 | = | 5.9 | uM | - |
| CHEMBL5564091 | — | EC90 | = | 7.4 | uM | - |
| CHEMBL5568534 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5560592 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5568375 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4128616 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5565189 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL5555908 | — | EC50 | > | 10000.0 | nM | - |
| CHEMBL4128616 | — | EC90 | > | 10.0 | uM | - |
| CHEMBL5568375 | — | EC90 | > | 10.0 | uM | - |
| CHEMBL5568017 | — | EC90 | = | 9.5 | uM | - |
| CHEMBL5561582 | — | EC90 | = | 9.9 | uM | - |
| CHEMBL5562068 | — | EC90 | = | 4.8 | uM | - |
| CHEMBL4802135 | NIRMATRELVIR | EC90 | = | 5.6 | uM | - |
| CHEMBL5560653 | — | EC90 | = | 9.3 | uM | - |
| CHEMBL5532059 | — | EC90 | = | 9.0 | uM | - |
| CHEMBL5560592 | — | EC90 | > | 10.0 | uM | - |
| CHEMBL4065616 | REMDESIVIR | EC90 | = | 4.7 | uM | - |
| CHEMBL5568534 | — | EC90 | > | 10.0 | uM | - |