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Compound Detail

CHEMBL5560653

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Cc1cc(C(=O)N[C@@H](Cc2cccc3ccccc23)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](C[C@@H]2CCCNC2=O)C(O)S(=O)(=O)[O-])no1.[Na+]

Basic Information

ChEMBL ID CHEMBL5560653
Phase Preclinical
Structure Type MOL
InChI Key AHCWKEYVVSUFJW-KHCMLEJHSA-M
Parent Compound CHEMBL6070816
Active Moiety CHEMBL6070816
2
Targets
6
Activities
1
Assay Types
0
PK Parameters
9
Publications
0
Known Names

Molecular Properties

671.8
MW (Da)
1.62
ALogP
9
HBA
6
HBD
217.0
PSA (Ų)
0.14
QED
2
Ro5 Violations
14
Rot. Bonds

Drug Information

Availability Unknown
Chirality Unknown

Flags

First in Class Prodrug

Extended Properties

Molecular Formula C32H40N5NaO9S
MW 693.75
Aromatic Rings 3
Heavy Atoms 47
NP-Likeness -0.33

Activity Summary

EC50 6 meas. best 6.52

Target Activity Profile

Target Type Best pChEMBL Mean pChEMBL Best (nM) # Data
SARS-CoV-2
CHEMBL4303835
EC50 6.52 6.058 300.0 5
Human coronavirus OC43
CHEMBL5209665
EC50 6.52 6.52 300.0 1

Activity Data Samples

Top measurements by pChEMBL value

Literature References

Data from ChEMBL 36 via Core Engine