Assay Detail
Functional
CHEMBL5508566
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Antiviral activity against Human coronavirus OC43 infected in Vero cells assessed as reduction in viral yield preincubated with virus for 1 hr followed by washout and compound treatment and measured after 3 days by qRT-PCR analysis
30
Total Activities
15
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Human coronavirus OC43 |
| Cell Type | Vero |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Synthesis and biological evaluation of novel peptidomimetic inhibitors of the coronavirus 3C-like protease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 15 | 5.94 | 8.00 |
| EC90 | 15 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4065616 | REMDESIVIR | 4.0 | 2 | 8.00 |
| CHEMBL5532059 | — | — | 2 | 7.00 |
| CHEMBL4802135 | NIRMATRELVIR | 4.0 | 2 | 6.70 |
| CHEMBL5562068 | — | — | 2 | 6.52 |
| CHEMBL5560653 | — | — | 2 | 6.52 |
| CHEMBL4129318 | — | — | 2 | 6.16 |
| CHEMBL5565189 | — | — | 2 | 6.16 |
| CHEMBL5561582 | — | — | 2 | 6.16 |
| CHEMBL5564091 | — | — | 2 | 6.10 |
| CHEMBL4128616 | — | — | 2 | 6.05 |
| CHEMBL5560592 | — | — | 2 | 5.14 |
| CHEMBL5555908 | — | — | 2 | 5.07 |
| CHEMBL5568375 | — | — | 2 | 4.75 |
| CHEMBL5568534 | — | — | 2 | 4.43 |
| CHEMBL5568017 | — | — | 2 | 4.27 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4065616 | REMDESIVIR | EC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5532059 | — | EC50 | = | 100.0 | nM | 7.00 |
| CHEMBL4802135 | NIRMATRELVIR | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL5562068 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL5560653 | — | EC50 | = | 300.0 | nM | 6.52 |
| CHEMBL4129318 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL5565189 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL5561582 | — | EC50 | = | 700.0 | nM | 6.16 |
| CHEMBL5564091 | — | EC50 | = | 800.0 | nM | 6.10 |
| CHEMBL4128616 | — | EC50 | = | 900.0 | nM | 6.05 |
| CHEMBL5560592 | — | EC50 | = | 7300.0 | nM | 5.14 |
| CHEMBL5555908 | — | EC50 | = | 8500.0 | nM | 5.07 |
| CHEMBL5568375 | — | EC50 | = | 18000.0 | nM | 4.75 |
| CHEMBL5568534 | — | EC50 | = | 36700.0 | nM | 4.43 |
| CHEMBL5568017 | — | EC50 | = | 53500.0 | nM | 4.27 |
| CHEMBL5564091 | — | EC90 | = | 2.6 | uM | - |
| CHEMBL4129318 | — | EC90 | = | 1.0 | uM | - |
| CHEMBL5555908 | — | EC90 | = | 47.6 | uM | - |
| CHEMBL5565189 | — | EC90 | = | 5.1 | uM | - |
| CHEMBL4128616 | — | EC90 | = | 7.0 | uM | - |
| CHEMBL5568375 | — | EC90 | = | 84.0 | uM | - |
| CHEMBL5568017 | — | EC90 | = | 99.0 | uM | - |
| CHEMBL5561582 | — | EC90 | = | 1.0 | uM | - |
| CHEMBL5562068 | — | EC90 | = | 0.8 | uM | - |
| CHEMBL5532059 | — | EC90 | = | 0.7 | uM | - |
| CHEMBL5560592 | — | EC90 | = | 9.7 | uM | - |
| CHEMBL5568534 | — | EC90 | = | 87.4 | uM | - |
| CHEMBL5560653 | — | EC90 | = | 0.7 | uM | - |
| CHEMBL4802135 | NIRMATRELVIR | EC90 | = | 0.3 | uM | - |
| CHEMBL4065616 | REMDESIVIR | EC90 | = | 0.03 | uM | - |