Assay Detail
Functional
CHEMBL5508573
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiviral activity against SARS-CoV-2 infected in human Calu-3 cells assessed as reduction in viral yield measured after 72 hrs by qRT-PCR analysis
8
Total Activities
4
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Cell Type | Calu-3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Target
SARS-CoV-2 (CHEMBL4303835) ↗| Type | ORGANISM |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
Synthesis and biological evaluation of novel peptidomimetic inhibitors of the coronavirus 3C-like protease.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 4 | 6.08 | 6.70 |
| EC90 | 4 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4065616 | REMDESIVIR | 4.0 | 2 | 6.70 |
| CHEMBL5532059 | — | — | 2 | 5.96 |
| CHEMBL5560653 | — | — | 2 | 5.92 |
| CHEMBL4802135 | NIRMATRELVIR | 4.0 | 2 | 5.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4065616 | REMDESIVIR | EC50 | = | 200.0 | nM | 6.70 |
| CHEMBL5532059 | — | EC50 | = | 1100.0 | nM | 5.96 |
| CHEMBL5560653 | — | EC50 | = | 1200.0 | nM | 5.92 |
| CHEMBL4802135 | NIRMATRELVIR | EC50 | = | 1900.0 | nM | 5.72 |
| CHEMBL5532059 | — | EC90 | = | 4.3 | uM | - |
| CHEMBL5560653 | — | EC90 | = | 5.3 | uM | - |
| CHEMBL4065616 | REMDESIVIR | EC90 | = | 0.7 | uM | - |
| CHEMBL4802135 | NIRMATRELVIR | EC90 | = | 7.6 | uM | - |