Assay Detail
Functional
CHEMBL5508618
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Antiproliferative activity against mouse BaF3 cells expressing FGFR2 incubated for 72 hrs by CCK-8 assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Mus musculus |
| Cell Type | BaF3 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of selective covalent inhibitors of FGFR4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.09 | 6.35 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5558986 | — | — | 1 | 6.35 |
| CHEMBL5565446 | — | — | 1 | 6.22 |
| CHEMBL5560176 | — | — | 1 | 5.71 |
| CHEMBL5559706 | — | — | 1 | - |
| CHEMBL5556135 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5558986 | — | IC50 | = | 445.0 | nM | 6.35 |
| CHEMBL5565446 | — | IC50 | = | 606.0 | nM | 6.22 |
| CHEMBL5560176 | — | IC50 | = | 1971.0 | nM | 5.71 |
| CHEMBL5559706 | — | IC50 | > | 5000.0 | nM | - |
| CHEMBL5556135 | — | IC50 | > | 5000.0 | nM | - |