Assay Detail
Functional
CHEMBL5508629
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human MDA-MB-453 cells after 72 hrs by CCK8 assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | MDA-MB-453 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Design, synthesis, and biological evaluation of selective covalent inhibitors of FGFR4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 6.13 | 6.43 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5558986 | — | — | 1 | 6.43 |
| CHEMBL5560176 | — | — | 1 | 6.14 |
| CHEMBL5556135 | — | — | 1 | 6.11 |
| CHEMBL5559706 | — | — | 1 | 6.05 |
| CHEMBL5565446 | — | — | 1 | 5.92 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5558986 | — | IC50 | = | 370.0 | nM | 6.43 |
| CHEMBL5560176 | — | IC50 | = | 730.0 | nM | 6.14 |
| CHEMBL5556135 | — | IC50 | = | 770.0 | nM | 6.11 |
| CHEMBL5559706 | — | IC50 | = | 890.0 | nM | 6.05 |
| CHEMBL5565446 | — | IC50 | = | 1190.0 | nM | 5.92 |