Assay Detail
Functional
CHEMBL5508989
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Antiproliferative activity against human HCT-116 cells assessed as inhibition of cell growth by CCK-8 assay
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | HCT-116 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Structure-based discovery of potent CARM1 inhibitors for colorectal cancer therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 6 | 5.31 | 5.53 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5558087 | — | — | 1 | 5.53 |
| CHEMBL5562404 | — | — | 1 | 5.50 |
| CHEMBL5556070 | — | — | 1 | 5.49 |
| CHEMBL5560201 | — | — | 1 | 5.48 |
| CHEMBL5561789 | — | — | 1 | 5.42 |
| CHEMBL5559689 | — | — | 1 | 4.42 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5558087 | — | IC50 | = | 2960.0 | nM | 5.53 |
| CHEMBL5562404 | — | IC50 | = | 3130.0 | nM | 5.50 |
| CHEMBL5556070 | — | IC50 | = | 3240.0 | nM | 5.49 |
| CHEMBL5560201 | — | IC50 | = | 3300.0 | nM | 5.48 |
| CHEMBL5561789 | — | IC50 | = | 3850.0 | nM | 5.42 |
| CHEMBL5559689 | — | IC50 | = | 38250.0 | nM | 4.42 |