Assay Detail
Functional
CHEMBL5509256
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Antiproliferative activity against human NCI-H929 cells assessed as reduction in cell viability
6
Total Activities
6
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Functional |
| Organism | Homo sapiens |
| Cell Type | NCI-H929 |
| Confidence | 1 — Organism |
| Curated By | Autocuration |
Publication
Targeting Myeloid Leukemia-1 in Cancer Therapy: Advances and Directions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| EC50 | 6 | 7.95 | 9.33 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5555963 | — | — | 1 | 9.33 |
| CHEMBL5538127 | — | — | 1 | 8.32 |
| CHEMBL4650225 | MURIZATOCLAX | 1.0 | 1 | 7.89 |
| CHEMBL4297482 | AZD-5991 | 1.0 | 1 | 7.50 |
| CHEMBL5542775 | — | — | 1 | 6.71 |
| CHEMBL4439276 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5555963 | — | EC50 | = | 0.47 | nM | 9.33 |
| CHEMBL5538127 | — | EC50 | = | 4.75 | nM | 8.32 |
| CHEMBL4650225 | MURIZATOCLAX | EC50 | = | 13.0 | nM | 7.89 |
| CHEMBL4297482 | AZD-5991 | EC50 | = | 31.7 | nM | 7.50 |
| CHEMBL5542775 | — | EC50 | = | 195.0 | nM | 6.71 |
| CHEMBL4439276 | — | EC50 | < | 10.0 | nM | - |