Assay Detail
Binding
CHEMBL5509268
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Binding affinity to mito 0.5-16 G4 DNA (unknown origin) assessed as dissociation constant measured upto 450 secs by surface plasmon resonance assay
10
Total Activities
10
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Not specified |
| Confidence | 3 — Cell-line / Tissue |
| Curated By | Autocuration |
Publication
Mitochondria-Selective Dicationic Small-Molecule Ligand Targeting G-Quadruplex Structures for Human Colorectal Cancer Therapy.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 10 | 6.42 | 6.96 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5563598 | — | — | 1 | 6.96 |
| CHEMBL5523646 | — | — | 1 | 6.82 |
| CHEMBL5562203 | — | — | 1 | 6.60 |
| CHEMBL5542132 | — | — | 1 | 6.55 |
| CHEMBL5559889 | — | — | 1 | 6.54 |
| CHEMBL5558153 | — | — | 1 | 6.39 |
| CHEMBL5560285 | — | — | 1 | 6.02 |
| CHEMBL5517891 | — | — | 1 | 5.99 |
| CHEMBL5566700 | — | — | 1 | 5.93 |
| CHEMBL5563400 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5563598 | — | Kd | = | 110.0 | nM | 6.96 |
| CHEMBL5523646 | — | Kd | = | 150.0 | nM | 6.82 |
| CHEMBL5562203 | — | Kd | = | 250.0 | nM | 6.60 |
| CHEMBL5542132 | — | Kd | = | 280.0 | nM | 6.55 |
| CHEMBL5559889 | — | Kd | = | 290.0 | nM | 6.54 |
| CHEMBL5558153 | — | Kd | = | 410.0 | nM | 6.39 |
| CHEMBL5560285 | — | Kd | = | 960.0 | nM | 6.02 |
| CHEMBL5517891 | — | Kd | = | 1020.0 | nM | 5.99 |
| CHEMBL5566700 | — | Kd | = | 1170.0 | nM | 5.93 |
| CHEMBL5563400 | — | Kd | > | 2000.0 | nM | - |