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Assay Detail

CHEMBL5509721

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Functional
Antiproliferative activity against human MV4-11 cells incubated for 120 hrs by Cell-Titer Glo assay
39
Total Activities
39
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type MV4-11
Confidence 1 — Organism
Curated By Autocuration

Target

MV4-11 (CHEMBL613835)
Type CELL-LINE
Organism Homo sapiens

Publication

Discovery of Highly Potent and Efficient CBP/p300 Degraders with Strong <i>In Vivo</i> Antitumor Activity.
Hu J, Xu H, Wu T, Zhang C, Shen H, Dong R, Hu Q, Xiang Q, Chai S, Luo G, Chen X, Huang Y, Zhao X, Peng C, Wu X, Lin B, Zhang Y, Xu Y.
J Med Chem (2024) 67 : 6952 -6986
PubMed 38649304 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 39 6.44 9.05

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5542816 1 9.05
CHEMBL5562829 1 8.74
CHEMBL5555598 1 8.24
CHEMBL4785363 INOBRODIB 1.0 1 7.69
CHEMBL5556224 1 7.52
CHEMBL5532556 1 7.36
CHEMBL5549858 1 7.07
CHEMBL5561968 1 7.06
CHEMBL5537067 1 6.95
CHEMBL5512525 1 6.88
CHEMBL5560186 1 6.78
CHEMBL5559554 1 6.66
CHEMBL5568190 1 6.65
CHEMBL5517806 1 6.58
CHEMBL5523495 1 6.56
CHEMBL5565604 1 6.39
CHEMBL5557002 1 6.33
CHEMBL5558018 1 6.28
CHEMBL5517659 1 6.22
CHEMBL5556071 1 6.01
CHEMBL5532493 1 6.00
CHEMBL5532086 1 5.99
CHEMBL5557048 1 5.94
CHEMBL5523662 1 5.93
CHEMBL5560010 1 5.91
CHEMBL5560498 1 5.78
CHEMBL5564619 1 5.77
CHEMBL5542828 1 5.77
CHEMBL5560106 1 5.76
CHEMBL5568053 1 5.76

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5542816 IC50 = 0.9 nM 9.05
CHEMBL5562829 IC50 = 1.8 nM 8.74
CHEMBL5555598 IC50 = 5.7 nM 8.24
CHEMBL4785363 INOBRODIB IC50 = 20.4 nM 7.69
CHEMBL5556224 IC50 = 30.1 nM 7.52
CHEMBL5532556 IC50 = 44.2 nM 7.36
CHEMBL5549858 IC50 = 84.8 nM 7.07
CHEMBL5561968 IC50 = 86.7 nM 7.06
CHEMBL5537067 IC50 = 111.5 nM 6.95
CHEMBL5512525 IC50 = 131.8 nM 6.88
CHEMBL5560186 IC50 = 164.7 nM 6.78
CHEMBL5559554 IC50 = 218.2 nM 6.66
CHEMBL5568190 IC50 = 222.7 nM 6.65
CHEMBL5517806 IC50 = 265.6 nM 6.58
CHEMBL5523495 IC50 = 273.0 nM 6.56
CHEMBL5565604 IC50 = 405.0 nM 6.39
CHEMBL5557002 IC50 = 464.1 nM 6.33
CHEMBL5558018 IC50 = 524.8 nM 6.28
CHEMBL5517659 IC50 = 606.0 nM 6.22
CHEMBL5556071 IC50 = 980.1 nM 6.01
CHEMBL5532493 IC50 = 1011.0 nM 6.00
CHEMBL5532086 IC50 = 1024.0 nM 5.99
CHEMBL5557048 IC50 = 1145.0 nM 5.94
CHEMBL5523662 IC50 = 1170.0 nM 5.93
CHEMBL5560010 IC50 = 1221.0 nM 5.91
CHEMBL5560498 IC50 = 1676.0 nM 5.78
CHEMBL5564619 IC50 = 1698.0 nM 5.77
CHEMBL5542828 IC50 = 1699.0 nM 5.77
CHEMBL5568053 IC50 = 1720.0 nM 5.76
CHEMBL5560106 IC50 = 1738.0 nM 5.76
CHEMBL5556530 IC50 = 1763.0 nM 5.75
CHEMBL5559898 IC50 = 1804.0 nM 5.74
CHEMBL5542117 IC50 = 1804.0 nM 5.74
CHEMBL5517656 IC50 = 1899.0 nM 5.72
CHEMBL5555132 IC50 = 2015.0 nM 5.70
CHEMBL5532022 IC50 = 2208.0 nM 5.66
CHEMBL5523541 IC50 = 2643.0 nM 5.58
CHEMBL5556463 IC50 = 6065.0 nM 5.22
CHEMBL5555446 IC50 > 10000.0 nM -