Compound Detail
CHEMBL5532022
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Cc1noc(C)c1-c1ccc2c(c1)nc([C@@H]1CCCC(=O)N1c1ccc(F)c(F)c1)n2C1CCN(CC(=O)NCCCCNc2ccc3c(c2)C(=O)N(C2CCC(=O)NC2=O)C3=O)CC1
Basic Information
| ChEMBL ID | CHEMBL5532022 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | RBUFSWIOTPKNMQ-SQTCDLSVSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
3
Publications
0
Known Names
Molecular Properties
890.0
MW (Da)
5.89
ALogP
12
HBA
3
HBD
192.1
PSA (Ų)
0.09
QED
3
Ro5 Violations
13
Rot. Bonds
Drug Information
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 5.66
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| MV4-11 CHEMBL613835 | IC50 | 5.66 | 5.66 | 2208.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| MV4-11 | IC50 | = | 2208.0 | nM | 5.66 | Antiproliferative activity against human MV4-11 cells incubated for 120 hrs by C... | 38649304 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 38649304 | 10.1021/acs.jmedchem.3c02195 | MV4-11 | 1 |
| 38649304 | 10.1021/acs.jmedchem.3c02195 | Protein cereblon/CREB-binding protein | 1 |
| 38649304 | 10.1021/acs.jmedchem.3c02195 | Protein cereblon/Histone acetyltransferase p300 | 1 |
Data from ChEMBL 36 via Core Engine