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Assay Detail

CHEMBL5510213

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Functional
Inhibition of cell growth in human RS4-11 cells incubated for 2 days by CellTiter-Glo luminescent cell viability assay
ChEMBL ↗
83
Total Activities
82
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Functional
Organism Homo sapiens
Cell Type RS4-11
Confidence 1 — Organism
Curated By Autocuration

Target

RS4-11 (CHEMBL2366159) ↗
Type CELL-LINE
Organism Homo sapiens

Publication

Discovery of the Clinical Candidate Sonrotoclax (BGB-11417), a Highly Potent and Selective Inhibitor for Both WT and G101V Mutant Bcl-2.
Guo Y, Xue H, Hu N, Liu Y, Sun H, Yu D, Qin L, Shi G, Wang F, Xin L, Sun W, Zhang F, Song X, Li S, Wei Q, Guo Y, Li Y, Liu X, Chen S, Zhang T, Wu Y, Su D, Zhu Y, Xu A, Xu H, Yang S, Zheng Z, Liu J, Yang X, Yuan X, Hong Y, Sun X, Guo Y, Zhou C, Liu X, Wang L, Wang Z.
J Med Chem (2024) 67 : 7836 -7858
PubMed 38695063 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
IC50 83 7.40 9.25

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5314951 SONROTOCLAX 3.0 1 9.25
CHEMBL5532549 — — 2 9.25
CHEMBL5556406 — — 1 9.15
CHEMBL5564290 — — 1 9.10
CHEMBL5568435 — — 1 9.00
CHEMBL5555281 — — 1 8.92
CHEMBL5561680 — — 1 8.89
CHEMBL5560614 — — 1 8.85
CHEMBL5560718 — — 1 8.85
CHEMBL5567138 — — 1 8.82
CHEMBL5560668 — — 1 8.80
CHEMBL5562694 — — 1 8.72
CHEMBL5567889 — — 1 8.60
CHEMBL5523428 — — 1 8.59
CHEMBL5558905 — — 1 8.49
CHEMBL3137309 VENETOCLAX 4.0 1 8.37
CHEMBL5557867 — — 1 8.24
CHEMBL5542719 — — 1 8.23
CHEMBL5567397 — — 1 8.20
CHEMBL5559861 — — 1 8.12
CHEMBL5314523 LACUTOCLAX 2.0 1 7.96
CHEMBL5562355 — — 1 7.96
CHEMBL5560955 — — 1 7.96
CHEMBL3701382 VOB-560 1.0 1 7.92
CHEMBL5567413 — — 1 7.89
CHEMBL5562626 — — 1 7.82
CHEMBL5565335 — — 1 7.77
CHEMBL5557016 — — 1 7.60
CHEMBL5556265 — — 1 7.57
CHEMBL5557735 — — 1 7.52

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5314951 SONROTOCLAX IC50 = 0.56 nM 9.25
CHEMBL5532549 — IC50 = 0.56 nM 9.25
CHEMBL5556406 — IC50 = 0.7 nM 9.15
CHEMBL5564290 — IC50 = 0.8 nM 9.10
CHEMBL5532549 — IC50 = 1.0 nM 9.00
CHEMBL5568435 — IC50 = 1.0 nM 9.00
CHEMBL5555281 — IC50 = 1.2 nM 8.92
CHEMBL5561680 — IC50 = 1.3 nM 8.89
CHEMBL5560614 — IC50 = 1.4 nM 8.85
CHEMBL5560718 — IC50 = 1.4 nM 8.85
CHEMBL5567138 — IC50 = 1.5 nM 8.82
CHEMBL5560668 — IC50 = 1.6 nM 8.80
CHEMBL5562694 — IC50 = 1.9 nM 8.72
CHEMBL5567889 — IC50 = 2.5 nM 8.60
CHEMBL5523428 — IC50 = 2.6 nM 8.59
CHEMBL5558905 — IC50 = 3.2 nM 8.49
CHEMBL3137309 VENETOCLAX IC50 = 4.3 nM 8.37
CHEMBL5557867 — IC50 = 5.8 nM 8.24
CHEMBL5542719 — IC50 = 5.9 nM 8.23
CHEMBL5567397 — IC50 = 6.3 nM 8.20
CHEMBL5559861 — IC50 = 7.6 nM 8.12
CHEMBL5314523 LACUTOCLAX IC50 = 11.0 nM 7.96
CHEMBL5562355 — IC50 = 11.0 nM 7.96
CHEMBL5560955 — IC50 = 11.0 nM 7.96
CHEMBL3701382 VOB-560 IC50 = 12.0 nM 7.92
CHEMBL5567413 — IC50 = 13.0 nM 7.89
CHEMBL5562626 — IC50 = 15.0 nM 7.82
CHEMBL5565335 — IC50 = 17.0 nM 7.77
CHEMBL5557016 — IC50 = 25.0 nM 7.60
CHEMBL5556265 — IC50 = 27.0 nM 7.57
CHEMBL5557735 — IC50 = 30.0 nM 7.52
CHEMBL5542692 — IC50 = 39.0 nM 7.41
CHEMBL5555045 — IC50 = 43.0 nM 7.37
CHEMBL5523480 — IC50 = 45.0 nM 7.35
CHEMBL5564702 — IC50 = 48.0 nM 7.32
CHEMBL5566790 — IC50 = 50.0 nM 7.30
CHEMBL5561534 — IC50 = 53.0 nM 7.28
CHEMBL5564159 — IC50 = 56.0 nM 7.25
CHEMBL5531998 — IC50 = 60.0 nM 7.22
CHEMBL5562291 — IC50 = 69.0 nM 7.16
CHEMBL5542608 — IC50 = 74.0 nM 7.13
CHEMBL5532350 — IC50 = 82.0 nM 7.09
CHEMBL5565924 — IC50 = 103.0 nM 6.99
CHEMBL5568440 — IC50 = 107.0 nM 6.97
CHEMBL5564343 — IC50 = 119.0 nM 6.92
CHEMBL5567807 — IC50 = 123.0 nM 6.91
CHEMBL5557529 — IC50 = 123.0 nM 6.91
CHEMBL5562147 — IC50 = 123.0 nM 6.91
CHEMBL5557944 — IC50 = 135.0 nM 6.87
CHEMBL5566724 — IC50 = 144.0 nM 6.84