Skip to main content
Free research Free research Free assay review with research home and workspace preview
Quick search ChEMBL 36
Assay Detail

CHEMBL5511040

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding
Binding affinity to human ATAD2B BRD assessed as dissociation constant by isothermal titration calorimetry
32
Total Activities
32
Compounds Tested
1
Activity Types
0
Assay Parameters

Assay Information

Assay Type Binding
Organism Homo sapiens
Confidence 9 — Direct single protein target
Curated By Autocuration

Target

ATPase family AAA domain-containing protein 2B (CHEMBL2176775)
Type SINGLE PROTEIN
Organism Homo sapiens

Publication

Impact of Combinatorial Histone Modifications on Acetyllysine Recognition by the ATAD2 and ATAD2B Bromodomains.
Phillips M, Malone KL, Boyle BW, Montgomery C, Kressy IA, Joseph FM, Bright KM, Boyson SP, Chang S, Nix JC, Young NL, Jeffers V, Frietze S, Glass KC.
J Med Chem (2024) 67 : 8186 -8200
PubMed 38733345 · DOI

Activity Statistics

Type Count Avg pChEMBL Best pChEMBL
Kd 32 4.35 4.71

Compounds Tested

Compound Name Phase Activities Best pChEMBL
CHEMBL5532358 1 4.71
CHEMBL5560329 1 4.64
CHEMBL5563291 1 4.64
CHEMBL5555514 1 4.59
CHEMBL5556488 1 4.54
CHEMBL5561637 1 4.54
CHEMBL5557160 1 4.51
CHEMBL5559128 1 4.47
CHEMBL5558328 1 4.45
CHEMBL5562837 1 4.32
CHEMBL5560159 1 4.32
CHEMBL5560110 1 4.32
CHEMBL5555867 1 4.30
CHEMBL5567708 1 4.26
CHEMBL5559165 1 4.20
CHEMBL5560828 1 4.18
CHEMBL5568300 1 4.11
CHEMBL5562582 1 4.10
CHEMBL4786330 1 4.08
CHEMBL5558274 1 4.05
CHEMBL5566389 1 4.02
CHEMBL5563077 1 -
CHEMBL5558146 1 -
CHEMBL5558843 1 -
CHEMBL5527978 1 -
CHEMBL4751427 1 -
CHEMBL5562594 1 -
CHEMBL5568029 1 -
CHEMBL5556056 1 -
CHEMBL5561085 1 -

Activity Data

Compound Name Type Rel. Value Units pChEMBL
CHEMBL5532358 Kd = 19400.0 nM 4.71
CHEMBL5560329 Kd = 22900.0 nM 4.64
CHEMBL5563291 Kd = 22800.0 nM 4.64
CHEMBL5555514 Kd = 25900.0 nM 4.59
CHEMBL5556488 Kd = 28600.0 nM 4.54
CHEMBL5561637 Kd = 29100.0 nM 4.54
CHEMBL5557160 Kd = 30900.0 nM 4.51
CHEMBL5559128 Kd = 34100.0 nM 4.47
CHEMBL5558328 Kd = 35600.0 nM 4.45
CHEMBL5562837 Kd = 47900.0 nM 4.32
CHEMBL5560159 Kd = 48200.0 nM 4.32
CHEMBL5560110 Kd = 47800.0 nM 4.32
CHEMBL5555867 Kd = 50500.0 nM 4.30
CHEMBL5567708 Kd = 55500.0 nM 4.26
CHEMBL5559165 Kd = 62800.0 nM 4.20
CHEMBL5560828 Kd = 66600.0 nM 4.18
CHEMBL5568300 Kd = 78300.0 nM 4.11
CHEMBL5562582 Kd = 79300.0 nM 4.10
CHEMBL4786330 Kd = 84200.0 nM 4.08
CHEMBL5558274 Kd = 90000.0 nM 4.05
CHEMBL5566389 Kd = 94600.0 nM 4.02
CHEMBL5563077 Kd - -
CHEMBL5558146 Kd - -
CHEMBL5558843 Kd - -
CHEMBL5527978 Kd - -
CHEMBL4751427 Kd - -
CHEMBL5562594 Kd - -
CHEMBL5568029 Kd - -
CHEMBL5556056 Kd - -
CHEMBL5561085 Kd - -
CHEMBL5555070 Kd - -
CHEMBL5562233 Kd - -