Assay Detail
Binding
CHEMBL5511283
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Binding affinity to human NSD3 PWWP1 domain (263 to 398 residues) expressed in Escherichia coli Bl21 (DE3) gold cells assessed as dissociation constant measured upto 180 secs by SPR analysis
12
Total Activities
12
Compounds Tested
2
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Histone-lysine N-methyltransferase NSD3 (CHEMBL3108646) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Identification of Novel Potent NSD2-PWWP1 Ligands Using Structure-Based Design and Computational Approaches.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| Kd | 9 | 5.75 | 6.90 |
| pKd | 3 | - | - |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4778517 | — | — | 1 | 6.90 |
| CHEMBL5559507 | — | — | 1 | 4.60 |
| CHEMBL5563959 | — | — | 1 | - |
| CHEMBL5560105 | — | — | 1 | - |
| CHEMBL5517868 | — | — | 1 | - |
| CHEMBL5559177 | — | — | 1 | - |
| CHEMBL5561556 | — | — | 1 | - |
| CHEMBL5527939 | — | — | 1 | - |
| CHEMBL5542933 | — | — | 1 | - |
| CHEMBL5556168 | — | — | 1 | - |
| CHEMBL5542423 | — | — | 1 | - |
| CHEMBL5566275 | — | — | 1 | - |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4778517 | — | Kd | = | 125.89 | nM | 6.90 |
| CHEMBL5559507 | — | Kd | = | 25118.86 | nM | 4.60 |
| CHEMBL5563959 | — | pKd | - | — | - | |
| CHEMBL5560105 | — | pKd | - | — | - | |
| CHEMBL5517868 | — | Kd | > | 31622.78 | nM | - |
| CHEMBL5559177 | — | Kd | > | 31622.78 | nM | - |
| CHEMBL5561556 | — | pKd | - | — | - | |
| CHEMBL5527939 | — | Kd | > | 31622.78 | nM | - |
| CHEMBL5542933 | — | Kd | > | 31622.78 | nM | - |
| CHEMBL5556168 | — | Kd | > | 31622.78 | nM | - |
| CHEMBL5542423 | — | Kd | > | 31622.78 | nM | - |
| CHEMBL5566275 | — | Kd | > | 31622.78 | nM | - |