Assay Detail
Binding
CHEMBL5511567
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of EGFR D770_N771insSVD mutant (unknown origin) phosphorylation transfected in human NCI-H2073 cells incubated for 2 hrs by ELISA
8
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | NCI-H2073 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Discovery and Optimization of Potent, Efficacious and Selective Inhibitors Targeting EGFR Exon20 Insertion Mutations.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 8 | 7.17 | 7.66 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4650319 | MOBOCERTINIB | 4.0 | 2 | 7.66 |
| CHEMBL4650281 | CLN-081 | 3.0 | 2 | 7.24 |
| CHEMBL5542205 | — | — | 2 | 7.07 |
| CHEMBL5517919 | — | — | 2 | 6.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4650319 | MOBOCERTINIB | IC50 | = | 22.0 | nM | 7.66 |
| CHEMBL4650281 | CLN-081 | IC50 | = | 57.0 | nM | 7.24 |
| CHEMBL5542205 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL5517919 | — | IC50 | = | 200.0 | nM | 6.70 |
| CHEMBL5517919 | — | IC50 | > | 707945784.38 | nM | - |
| CHEMBL5542205 | — | IC50 | > | 707945784.38 | nM | - |
| CHEMBL4650319 | MOBOCERTINIB | IC50 | > | 707945784.38 | nM | - |
| CHEMBL4650281 | CLN-081 | IC50 | > | 707945784.38 | nM | - |