Assay Detail
Binding
CHEMBL5512987
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of recombinant SARS-CoV-2 3CLp using fluorogenic substrate by microplate reader
7
Total Activities
7
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Replicase polyprotein 1ab (CHEMBL4523582) ↗| Type | SINGLE PROTEIN |
| Organism | Severe acute respiratory syndrome coronavirus 2 |
Publication
Development of de-novo coronavirus 3-chymotrypsin-like protease (3CL<sup>pro</sup>) inhibitors since COVID-19 outbreak: A strategy to tackle challenges of persistent virus infection.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 7 | 7.89 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5275166 | — | — | 1 | 8.05 |
| CHEMBL5276490 | — | — | 1 | 8.05 |
| CHEMBL5288416 | — | — | 1 | 8.00 |
| CHEMBL5195325 | — | — | 1 | 7.85 |
| CHEMBL5270743 | — | — | 1 | 7.80 |
| CHEMBL5564996 | — | — | 1 | 7.75 |
| CHEMBL5267952 | — | — | 1 | 7.72 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5275166 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL5276490 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL5288416 | — | IC50 | = | 10.0 | nM | 8.00 |
| CHEMBL5195325 | — | IC50 | = | 14.0 | nM | 7.85 |
| CHEMBL5270743 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL5564996 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL5267952 | — | IC50 | = | 19.0 | nM | 7.72 |