Assay Detail
Binding
CHEMBL5513255
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of PLK4 (unknown origin) by discoverX kinome scan assay
5
Total Activities
5
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase PLK4 (CHEMBL3788) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Therapeutic potential of targeting polo-like kinase 4.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.99 | 10.00 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5209160 | — | — | 1 | 10.00 |
| CHEMBL5171469 | — | — | 1 | 9.52 |
| CHEMBL5179518 | — | — | 1 | 7.67 |
| CHEMBL5175418 | — | — | 1 | 6.45 |
| CHEMBL5186873 | — | — | 1 | 6.32 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5209160 | — | IC50 | = | 0.1 | nM | 10.00 |
| CHEMBL5171469 | — | IC50 | = | 0.3 | nM | 9.52 |
| CHEMBL5179518 | — | IC50 | = | 21.2 | nM | 7.67 |
| CHEMBL5175418 | — | IC50 | = | 351.5 | nM | 6.45 |
| CHEMBL5186873 | — | IC50 | = | 483.9 | nM | 6.32 |