Assay Detail
Binding
CHEMBL5513346
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of BRD4 BD1 (unknown origin) using N-C:SGRG-K(Ac)-GG K(Ac)-GLG-K(Ac)-GGA-K(Ac)-RHRKVGG-K(biotin) as substrate preincubated for 15 mins followed by substrate addition and measured for 60 mins by ALPHA screen assay
2
Total Activities
2
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
Novel small molecule inhibitors targeting renal cell carcinoma: Status, challenges, future directions.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 2 | 6.28 | 6.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL5560492 | — | — | 1 | 6.54 |
| CHEMBL1454910 | NITROXOLINE | 4.0 | 1 | 6.01 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL5560492 | — | IC50 | = | 287.0 | nM | 6.54 |
| CHEMBL1454910 | NITROXOLINE | IC50 | = | 980.0 | nM | 6.01 |