Assay Detail
Binding
CHEMBL5513490
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of human ULK1 by discoverX kinome scan assay
5
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase ULK1 (CHEMBL6006) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Targeting autophagy drug discovery: Targets, indications and development trends.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 5 | 7.88 | 8.54 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL4516990 | — | — | 1 | 8.54 |
| CHEMBL4744680 | — | — | 1 | 8.08 |
| CHEMBL73157 | — | — | 2 | 7.89 |
| CHEMBL3605057 | — | — | 1 | 7.35 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL4516990 | — | IC50 | = | 2.9 | nM | 8.54 |
| CHEMBL4744680 | — | IC50 | = | 8.3 | nM | 8.08 |
| CHEMBL73157 | — | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL73157 | — | IC50 | = | 30.0 | nM | 7.52 |
| CHEMBL3605057 | — | IC50 | = | 45.0 | nM | 7.35 |