Compound Detail
CHEMBL73157
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL73157 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | XKTUKRBLWOHYIL-MLPAPPSSSA-N |
3
Targets
6
Activities
1
Assay Types
0
PK Parameters
9
Publications
0
Known Names
Molecular Properties
400.2
MW (Da)
5.02
ALogP
4
HBA
2
HBD
79.5
PSA (Ų)
0.48
QED
1
Ro5 Violations
3
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 6 meas. best 7.89
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| Serine/threonine-protein kinase ULK1 CHEMBL6006 | IC50 | 7.89 | 7.26 | 13.0 | 3 |
| RAF proto-oncogene serine/threonine-protein kinase CHEMBL1906 | IC50 | 7.4 | 7.4 | 40.0 | 1 |
| Kinesin-like protein KIF15 CHEMBL3632454 | IC50 | 6.12 | 6.105 | 750.0 | 2 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| Serine/threonine-protein kinase ULK1 | IC50 | = | 13.0 | nM | 7.89 | Inhibition of human ULK1 by discoverX kinome scan assay | 38295689 |
| Serine/threonine-protein kinase ULK1 | IC50 | = | 30.0 | nM | 7.52 | Inhibition of human ULK1 by discoverX kinome scan assay | 38295689 |
| RAF proto-oncogene serine/threonine-protein kinase | IC50 | = | 40.0 | nM | 7.4 | Inhibition of cRaf1 kinase in cascade assay | 10698440 |
| Serine/threonine-protein kinase ULK1 | IC50 | = | 427.0 | nM | 6.37 | Inhibition of ULK1 (unknown origin) | 38432059 |
| Kinesin-like protein KIF15 | IC50 | = | 750.0 | nM | 6.12 | Inhibition of recombinant His6-tagged Kif15 (N700 residues) (unknown origin) exp... | 30528696 |
| Kinesin-like protein KIF15 | IC50 | = | 820.0 | nM | 6.09 | Inhibition of recombinant His6-tagged Kif15 ATPase activity (N420 residues) (unk... | 30528696 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 30528696 | 10.1016/j.bmcl.2018.12.008 | Kinesin-like protein KIF15 | 14 |
| 38295689 | 10.1016/j.ejmech.2023.116117 | Serine/threonine-protein kinase ULK1 | 2 |
| 10698440 | 10.1016/s0960-894x(99)00668-x | RAF proto-oncogene serine/threonine-protein kinase | 1 |
| 10698440 | 10.1016/s0960-894x(99)00668-x | Unchecked | 1 |
| 30528696 | 10.1016/j.bmcl.2018.12.008 | Kinesin-like protein KIF11 | 1 |
| 30528696 | 10.1016/j.bmcl.2018.12.008 | Kinesin-like protein KIFC1 | 1 |
| 30528696 | 10.1016/j.bmcl.2018.12.008 | Kinesin-like protein KIF18A | 1 |
| 30528696 | 10.1016/j.bmcl.2018.12.008 | Aurora kinase A | 1 |
| 38432059 | 10.1016/j.ejmech.2024.116273 | Serine/threonine-protein kinase ULK1 | 1 |
Data from ChEMBL 36 via Core Engine