Assay Detail
Binding
CHEMBL820190
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Inhibition of cRaf1 kinase in cascade assay
12
Total Activities
12
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Confidence | 8 — Homologous single protein target |
| Curated By | Expert |
Target
RAF proto-oncogene serine/threonine-protein kinase (CHEMBL1906) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
The discovery of potent cRaf1 kinase inhibitors.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 12 | 7.49 | 8.05 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL1794051 | — | — | 1 | 8.05 |
| CHEMBL1794050 | GW429374A | — | 1 | 7.96 |
| CHEMBL1794052 | GW405841X | — | 1 | 7.89 |
| CHEMBL418892 | — | — | 1 | 7.80 |
| CHEMBL73554 | — | — | 1 | 7.75 |
| CHEMBL75988 | — | — | 1 | 7.60 |
| CHEMBL311402 | — | — | 1 | 7.54 |
| CHEMBL73470 | — | — | 1 | 7.50 |
| CHEMBL73157 | — | — | 1 | 7.40 |
| CHEMBL1789963 | GW406108X | — | 1 | 7.34 |
| CHEMBL72179 | — | — | 1 | 7.19 |
| CHEMBL75275 | — | — | 1 | 5.89 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL1794051 | — | IC50 | = | 9.0 | nM | 8.05 |
| CHEMBL1794050 | GW429374A | IC50 | = | 11.0 | nM | 7.96 |
| CHEMBL1794052 | GW405841X | IC50 | = | 13.0 | nM | 7.89 |
| CHEMBL418892 | — | IC50 | = | 16.0 | nM | 7.80 |
| CHEMBL73554 | — | IC50 | = | 18.0 | nM | 7.75 |
| CHEMBL75988 | — | IC50 | = | 25.0 | nM | 7.60 |
| CHEMBL311402 | — | IC50 | = | 29.0 | nM | 7.54 |
| CHEMBL73470 | — | IC50 | = | 32.0 | nM | 7.50 |
| CHEMBL73157 | — | IC50 | = | 40.0 | nM | 7.40 |
| CHEMBL1789963 | GW406108X | IC50 | = | 46.0 | nM | 7.34 |
| CHEMBL72179 | — | IC50 | = | 65.0 | nM | 7.19 |
| CHEMBL75275 | — | IC50 | = | 1300.0 | nM | 5.89 |