Compound Detail
CHEMBL418892
Enter ChEMBL ID:
Free Research Context
This compound will appear in recent viewed items on the research home for this browser.
Research home
View demo workspace
Basic Information
| ChEMBL ID | CHEMBL418892 |
| Phase | Preclinical |
| Structure Type | MOL |
| InChI Key | PAINBGJMBJLNBC-CLTKARDFSA-N |
1
Targets
1
Activities
1
Assay Types
0
PK Parameters
2
Publications
0
Known Names
Molecular Properties
467.1
MW (Da)
4.60
ALogP
5
HBA
3
HBD
88.2
PSA (Ų)
0.46
QED
0
Ro5 Violations
1
Rot. Bonds
Drug Information
| Molecule Type | Small molecule |
| Availability | Unknown |
| Chirality | Unknown |
Activity Summary
IC50 1 meas. best 7.8
Target Activity Profile
| Target | Type | Best pChEMBL | Mean pChEMBL | Best (nM) | # Data |
|---|---|---|---|---|---|
| RAF proto-oncogene serine/threonine-protein kinase CHEMBL1906 | IC50 | 7.8 | 7.8 | 16.0 | 1 |
Activity Data Samples
Top measurements by pChEMBL value
| Target | Type | Rel. | Value | Units | pChEMBL | Assay | PubMed |
|---|---|---|---|---|---|---|---|
| RAF proto-oncogene serine/threonine-protein kinase | IC50 | = | 16.0 | nM | 7.8 | Inhibition of cRaf1 kinase in cascade assay | 10698440 |
Literature References
| PubMed | DOI | Target Context | # Activities |
|---|---|---|---|
| 10698440 | 10.1016/s0960-894x(99)00668-x | RAF proto-oncogene serine/threonine-protein kinase | 1 |
| 10698440 | 10.1016/s0960-894x(99)00668-x | Unchecked | 1 |
Data from ChEMBL 36 via Core Engine