Assay Detail
Binding
CHEMBL5513492
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of mTOR (unknown origin) by lanthascreen kinase assay
3
Total Activities
3
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Target
Serine/threonine-protein kinase mTOR (CHEMBL2842) ↗| Type | SINGLE PROTEIN |
| Organism | Homo sapiens |
Publication
Targeting autophagy drug discovery: Targets, indications and development trends.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 3 | 9.43 | 10.30 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL413 | SIROLIMUS | 4.0 | 1 | 10.30 |
| CHEMBL592445 | GEDATOLISIB | 3.0 | 1 | 9.40 |
| CHEMBL1078983 | Ku-0063794 | — | 1 | 8.60 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL413 | SIROLIMUS | IC50 | = | 0.05 | nM | 10.30 |
| CHEMBL592445 | GEDATOLISIB | IC50 | = | 0.4 | nM | 9.40 |
| CHEMBL1078983 | Ku-0063794 | IC50 | = | 2.5 | nM | 8.60 |