Assay Detail
Binding
CHEMBL5513574
Review assay metadata, readout intent, target linkage, and publication context from the same page.
Inhibition of NHE1 in human Platelet assessed as change in intracellular pH by pH-sensitive BCECF-AM fluorescence probe method
4
Total Activities
4
Compounds Tested
1
Activity Types
0
Assay Parameters
Assay Information
| Assay Type | Binding |
| Organism | Homo sapiens |
| Cell Type | Platelet |
| Confidence | 9 — Direct single protein target |
| Curated By | Autocuration |
Publication
pH regulators and their inhibitors in tumor microenvironment.
Activity Statistics
| Type | Count | Avg pChEMBL | Best pChEMBL |
|---|---|---|---|
| IC50 | 4 | 6.94 | 7.23 |
Compounds Tested
| Compound | Name | Phase | Activities | Best pChEMBL |
|---|---|---|---|---|
| CHEMBL355862 | ZONIPORIDE | 2.0 | 1 | 7.23 |
| CHEMBL5562354 | — | — | 1 | 7.07 |
| CHEMBL1256180 | 5-(N-METHYL-N-ISOBUTYL)AMILORIDE | — | 1 | 6.76 |
| CHEMBL3526475 | — | — | 1 | 6.70 |
Activity Data
| Compound | Name | Type | Rel. | Value | Units | pChEMBL |
|---|---|---|---|---|---|---|
| CHEMBL355862 | ZONIPORIDE | IC50 | = | 59.0 | nM | 7.23 |
| CHEMBL5562354 | — | IC50 | = | 85.0 | nM | 7.07 |
| CHEMBL1256180 | 5-(N-METHYL-N-ISOBUTYL)AMILORIDE | IC50 | = | 174.0 | nM | 6.76 |
| CHEMBL3526475 | — | IC50 | = | 200.0 | nM | 6.70 |