Assay Detail

CHEMBL5514023

Review assay metadata, readout intent, target linkage, and publication context from the same page.

Binding

Inhibition of rat steroid 5-alpha-reductase 1

ChEMBL ↗

Free Research Context This assay will appear in recent viewed items on this browser. Open the demo workspace to preview project-only review queues.

Research home Demo workspace

Target

3-oxo-5-alpha-steroid 4-dehydrogenase 1 (CHEMBL3422) ↗

Open DB target context

Use one target anchor to keep assay intent, target linkage, and tested compound review aligned.

Loading context

3-oxo-5-alpha-steroid 4-dehydrogenase 1 (CHEMBL3422) is the working anchor for this assay review. Loading the live Open DB target snapshot…

Primary target 3-oxo-5-alpha-steroid 4-dehydrogenase 1

CHEMBL3422

Anchored from Assay target.

Protein identity 3-oxo-5-alpha-steroid 4-dehydrogenase 1

Disease frame Disease evidence pending

Open the live target snapshot or evidence card before reviewing assay metadata so target fit and disease framing stay reusable.

Review focus Open DB context pending

Open the live target snapshot before relying on this target frame across surface handoff.

Open target snapshot Open evidence card Search with this context

Total Activities

Compounds Tested

Activity Types

Assay Parameters

Assay Information

Assay Type	Binding
Organism	Rattus norvegicus
Confidence	9 — Direct single protein target
Curated By	Autocuration

Target

3-oxo-5-alpha-steroid 4-dehydrogenase 1 (CHEMBL3422) ↗

Type	SINGLE PROTEIN
Organism	Rattus norvegicus

Publication

Small-molecule agents for treating skin diseases.

Cai H, Wen H, Li J, Lu L, Zhao W, Jiang X, Bai R.
Eur J Med Chem (2024) 268 : 116269 -116269
PubMed 38422702 · DOI

Activity Statistics

Type	Count	Avg pChEMBL	Best pChEMBL
IC50	1	9.32	9.32

Compounds Tested

Compound	Name	Phase	Activities	Best pChEMBL
CHEMBL90085	—	—	1	9.32

Activity Data

Compound	Name	Type	Rel.	Value	Units	pChEMBL
CHEMBL90085	—	IC50	=	0.48	nM	9.32